ABSTRACT
Acne vulgaris is a very common disorder affecting virtually every adolescent at some point in time. Topical treatment of acne involves the use of retinoids and antimicrobials. Antimicrobials reduce P. acne population and are effective for treatment of inflammatory lesions. We evaluated the efficacy and safety of topical ciprofloxacin solution and compared it with topical erythromycin solution. The study was a prospective single-blind clinical trial. One hundred patients with mild to moderate acne were enrolled. The patients were randomly treated with topical application of 0.3% ciprofloxacin or 4% erythromycin solutions. For a six week period, they were visited every two weeks. Acne severity index [ASI] was calculated in each visit and recorded. Ninety-three patients completed the study, 50 patients in the ciprofloxacin and 43 in the erythromycin groups. Irritation was generally mild for both treatments and no discontinuation was reported because of adverse effects. There was no statistically significant difference between the two treatment groups in reduction of comedons or papules but reduction of pustules was greater in ciprofloxacin treatment group after 4 weeks. ASI was reduced in the two groups but in ciprofloxacin treated patients, this reduction was more significant at all follow up visits. The results of this study indicate that topical solutions of erythromycin and ciprofloxacin were effective in treating mild to moderate acne vulgaris and both were well-tolerated by the patients. Ciprofloxacin solution produced greater reduction in pustule counts and ASI, during the six week period of twice-daily application. This novel modality may have an important potential role in rotational topical therapy of inflammatory acne lesions
Subject(s)
Humans , Male , Female , Acne Vulgaris/microbiology , Ciprofloxacin/administration & dosage , Ciprofloxacin , Erythromycin/administration & dosage , Erythromycin , Ciprofloxacin/adverse effects , Erythromycin/adverse effects , Propionibacterium acnes/drug effects , Administration, Topical , Prospective StudiesABSTRACT
Ao se apresentar um caso de celulite orbitária, tem-se de ressaltar a um só tempo as peculiaridades concernentes a esta entidade nosológica, bem como a evoluçäo eventualmente tórpida que tal quadro pode assumir. Uma jovem negra de 25 anos, relatava apenas uma pápula acneica contaminada, provavelmente pelo S. aureus, é que a seguir evoluiu para celulite orbitária, complicando com o aparecimento de meningite bacteriana secundada com empiema subdural
Subject(s)
Humans , Female , Adult , Acne Vulgaris/microbiology , Brain Abscess/etiology , Cellulitis/physiopathology , Orbital Diseases/diagnosis , Rhabdomyosarcoma , Diagnosis, Differential , Orbital Diseases/etiology , Orbital Neoplasms/diagnosisABSTRACT
A total of 200 patients [112 males and 88 females], mean age 20.4 years, with various acne lesions were studied. The most common organisms isolated from 99 pustule lesions were S. epidermidis [68.2%], and P. acnes from 79 samples [54.4%]. Comedons revealed growth of P. acnes in 49 cases [75.3%], and Staph. epidermidis in 40 samples [61.5%]. Rate of isolation of P. acnes from closed comedons was higher than that isolated from open comedons. There were significant elevations in the serum immunoglobulins [IgA and IgG] and serum complement fraction [C3 and C4] [P Value < 0.005]. Immunoglobulin deposits were detected in 49 of acne patients by indirect immunofluorescence technique
Subject(s)
Humans , Acne Vulgaris/microbiology , Acne Vulgaris/etiology , Bacteria/pathogenicity , Staphylococcus/isolation & purificationABSTRACT
Con el propósito de establecer diferencias en la flora bacteriana existente a nivel del folículo pilosebáceo de adolescentes con acné se estudiaron 50 pacientes con esta patología y 27 controles pareados por edad y sexo. Se obtuvo desarrollo de propionibacterium acnés en 76 por ciento de los adolescentes con acné y en 51,8 por ciento de controles, diferencias no significativas estadísticamente. En el grupo con acné, el P. acnés se cultivó en abundante cantidad (50 o mas colonias) en un 50 por ciento de los casos, regular cantidad en 42 por ciento, respecto del grupo control el desarrollo fue abundante en 42,8 por ciento y regular en 28,6 por ciento. En relación a flora aerobia, staphylococcus epidermis se aisló en 76,4 por ciento de pacientes con acné y 70,3 por ciento de controles. En la serie de pacientes estudiados observamos diferencia cualitativa respecto a presencia de P. acnés, pero no cuantitativa
Subject(s)
Humans , Male , Female , Adolescent , Acne Vulgaris/microbiology , Bacteria, Aerobic/isolation & purification , Bacteria, Anaerobic/isolation & purification , Propionibacterium acnes/isolation & purification , Skin/microbiologyABSTRACT
El acné es una patología frecuente en adolescentes cuya patogenia es multifactorial, influyendo factores hormonales y también se ha postulado como importante el rol del propionebacterium acnes tanto en la lesión primaria, el comedón, como en la inflamación folicular. Apoyando esta hipótesis han demostrado ser eficaces en el tratamiento del acné diversos antimicrobianos administrados por vía oral y/o local. En este estudio se evaluó la eficacia clínico-bacteriológica de una solución tópica de eritromicina al 2 por ciento (Abboderm) en acné. De 50 adolescentes ingresados, se analizaron 34 que continuaron en control. Tosdos los pacientes presentaban acné vulgar (comedoniano, pustuloso o quístico) y se les indicó eritromicina tópica 2 veces al día por 10 semanas, efectuando controles clínicos bisemanales y estudio bacteriológico previo, 6a. y 10a. semana La respuesta clínica observada fue excelente o buena (con reducción del 50 por ciento o mas de las lesiones) en el 76,4 por ciento de los pacientes a las 6 semanas de tratamiento. Un paciente fue retirado del estudio por efectos adversos. Se observó buena colrrelación entre la respuesta clínica y la disminución de P. acnes, que estaba presente en abundante o regular cantidad en 73,5 por ciento de los pacientes al inicio y sólo en el 13,0 por ciento a la 10a. semana. La flora aerobia S. epidermidis no mostró variaciones cuali ni cuantitativas